Endocrine Abstracts

Introduction: There is a long delay between the onset of symptoms and correct diagnosis of acromegaly. This study aimed to explore the potential of hand size as a screening tool of acromegaly. Here we present first results of a new screening project.Method: We measured scan-copies of acromegalics (n=27, 9 women, age 18–84 years) and controls (n=111, 71 women, age 19–81 years) and analyzed surface areas of palm and thenar and m...

Introduction: It has been shown that face classification software might help distinguishing between subjects with and without acromegaly on regular photographs. In this project, we investigated several aspects that will be necessary and helpful to bring this recognition method closer to clinical application.Methods: Face classification was based on nodes placed on frontal and side photographs of individuals and analysis the underlying texture and geometr...

Recent evidence shows that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. However, the pathomechanisms are still not completely understood. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we assessed morphological abormalities of the sella region in patients with TBI and their relation to endocrine function.We have studied MR or CT sc...

Introduction: Cushing’s syndrome (CS) is a rare disease characterized by clinical features that show overlap with the ‘metabolic syndrome’. Pilot studies regarding the use facial image analysis software as a novel diagnostic tool in acromegaly and CS have shown promising results. Distinguishing CS patients from patients that show similar features without true hypercortisolism remains a challenge in clinical practice. To address this particular problem, we evalua...

X-linked IGSF1 (immunoglobulin superfamily, member 1) loss-of-function mutations in males are associated with central hypothyroidism, macroorchidism, and a variable spectrum of anterior pituitary dysfunction. Igsf1 deficient male mice also exhibit central hypothyroidism, however, the physiological and molecular function of IGSF1 in both species has not yet been elucidated. Although partial transient GH deficiency is a ra...

X-linked IGSF1 (immunoglobulin superfamily, member 1) loss-of-function mutations in males are associated with central hypothyroidism, macroorchidism, and a variable spectrum of anterior pituitary dysfunction. Igsf1 deficient male mice also exhibit central hypothyroidism, however, the physiological and molecular function of IGSF1 in both species has not yet been elucidated. Although partial transient GH deficiency is a ra...